• br Materials and methods Rat forebrains were obtained from S

  2022-05-26

  

  Materials and methods Rat forebrains were obtained from Sprague–Dawley rats at 2, 7, 14, 21, and 30–35 postnatal days and were homogenized in 1:5 volumes (w/v) of 0.32 M sucrose containing 1 mM EGTA, 1 mM EDTA, 1 μg/ml TPCK, 50 μM leupeptin, and 3 μM antipain with 10 strokes in a glass-teflon hom

• Although most of the incretin effects on glucose metabolism

  2022-05-26

  

  Although most of the incretin effects on histamine receptor metabolism can be secondary to their action on insulin/glucagon secretion, some evidence strongly suggests that they could also act directly on liver glucose utilization and production [4], [13], [22], [27], [34], [44]. Supporting this con

• Ki16425 br Introduction Glucose homeostasis is

  2022-05-26

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β Ki16425 is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory hormon

• When testing the novel DA

  2022-05-26

  

  When testing the novel DA-CH3 peptide, it was found that it is superior to liraglutide in the MPTP mouse model of PD at a dose of 25 nmol/kg ip once-daily for 7 days. In the Rotarod and grip strength assessment, DA-CH3 was superior to liraglutide in reversing the MPTP–induced motor impairment. Dopam

• PS341 Cx has been shown to be serine phosphorylated by

  2022-05-26

  

  Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa PS341 [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the roles of both

• br Some general considerations on anterior pituitary cell

  2022-05-26

  

  Some general considerations on anterior pituitary cell type, models, sex and drugs Historically, real-time analysis of native endocrine anterior pituitary cell excitability has been somewhat limited and thus much of the pioneering work on anterior pituitary cell excitability and stimulus-secretio

• Inhibitors against the proteasome a component

  2022-05-26

  

  Inhibitors against the proteasome, a component of the ubiquitin-proteasome pathway that degrades cellular proteins, provide a new strategy for targeting the 26S proteasome [25]. Proteasome inhibitors can exhibit potent anti-cancer effects against different tumor bimatoprost and were shown to induce

• At present many methods have been applied

  2022-05-26

  

  At present, many methods have been applied for multiple detection. For example, BI-D1870 [[9], [10], [11]] is frequently used to detect multiple targets because of its exquisite sensitivity and specificity, but it is difficult to design experiments to test short-length oligonucleotides. Electrochem

• br Experimental Procedures Information on the materials used

  2022-05-26

  

  Experimental Procedures Information on the materials used in this study and the details of how the in vivo and in vitro assays were performed are provided in Supplemental Information. Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) grant funded b

• Earlier we have showed that tumor

  2022-05-26

  

  Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is

• It is known that microglial function

  2022-05-26

  

  It is known that microglial function and morphology are closely related [20], but no studies have addressed whether neuroinflammation induced by alcohol might modify microglial 2-Chlorotrityl Chloride Resin (i.e. morphology, neuroimmunochemical phenotype) through an eCB-dependent mechanism. Since t

• Here we employ a genetic approach to

  2022-05-26

  

  Here we employ a genetic approach to examine the potential interaction of Gli3 and Ezh2 with respect to anteroposterior limb bud polarity. Loss of Ezh2 in a Gli3 mutant background leads to synergistic loss of anterior identity, although the double mutant phenotype more closely resembles that of Ezh2

• To our knowledge the putative role of ET and

  2022-05-26

  

  To our knowledge, the putative role of ET-1 and ETB-R in oligodendroglioma progression was not documented so far. Using primary cultures of grade B oligodendroglial tumor cells, we have here assessed the functionality of ETB-R expression in these tumors. Confocal microscopy analysis confirmed the st

• The Jumonji JmjC domain containing KDM family members

  2022-05-26

  

  The Jumonji (JmjC) domain-containing KDM family members can be clustered into seven subfamilies (KDM2 – KDM8). The KDM2 cluster catalyzes H3K36me2/me1 demethylation; in addition, KDM2B/JHDM1B/FBXL10 has been suggested to catalyze demethylation of H3K4me3 [3]. Cell culture studies support that KDM2 p

• Electrochemical techniques have attracted broad attention fo

  2022-05-26

  

  Electrochemical techniques have attracted broad attention for their outstanding advantages, such as satisfactory sensitivity and convenient operation. Nowadays, nucleic Ac-DEVD-pNA nanostructures such as DNA tetrahedron structure, nucleic acid-mimicking structure, exhibit noticeable application in t

14960 records 445/998 page Previous Next First page 上5页 441442443444445 下5页 Last page