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Senexin B and br Conclusions br Conflict of interest stateme
2019-10-15
Conclusions Conflict of interest statement Acknowledgments This research was funded by São Paulo Research Foundation (FAPESP) (ProcessN. 2012/08621-1). Thanks to F.J.H. Blázquez and the staff of the Laboratório de Anatomia Microscópica e Imuno Histoquímica (LAMIH − FMVZ − USP) for the permi
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MI-77301 clinical Here we found that these leukotriene antag
2019-10-15
Here we found that these leukotriene antagonists also inhibit the effects of nucleotides acting at P2Y receptors in dU937 cells, which are known to express a number of nucleotide receptors, such as P2Y2 or P2Y4[30]. In an effort to characterize the P2 receptor subtypes subject to negative modulation
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Perturbation in the cytokine network is correlated with disr
2019-10-15
Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg
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br CDK Inhibitors for the Treatment of inflammatory Diseases
2019-10-15
CDK Inhibitors for the Treatment of inflammatory Diseases Several CDKs have been implicated as regulators of inflammatory gene expression. It will thus be very important to determine the relative contributions of the various CDKs and their kinase function on a systematic basis. This work will be
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Our results for imidacloprid were unexpected considering tha
2019-10-15
Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic NS 1619 pathway receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentratio
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The following are the supplementary
2019-10-15
The following are the supplementary data related to this article. Acknowledgments Introduction Cyclooxygenases metabolize arachidonic Aurora Kinase Inhibitor III to five primary prostanoids, PGE2, PGF2, PGI2, TXA2 (TX), and PGD2. These lipid mediators interact with specific members of a fami
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While agnathans appear to have reduced
2019-10-15
While agnathans appear to have reduced their Ednr repertoire to the Ednra gene (that may have been amplified in the Arctic lamprey), gnathostomes in general have been relatively inert to Ednr gene loss. Strikingly, the only Ednr gene that has been lost repeatedly is EdnrB2 (lost in therian mammals,
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L-Homopropargyl Glycine br Acknowledgments br Introduction H
2019-10-15
Acknowledgments Introduction Hypertensive retinopathy is a disease of the retinal microvasculature associated with elevated blood pressure (Fraser-Bell et al., 2017). Narrowing of retinal arterioles occurs in the early stage of the disease, and with persistent hypertension further vascular pat
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The imaging and biochemical data presented here demonstrated
2019-10-15
The imaging and biochemical data presented here demonstrated that in T cells, AEP played a specific function in cleaving Foxp3 but not Tbet. These results are in accordance with previous AEP studies where it has been shown that AEP substrates in part are not amenable to other protease activity. In a
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Introduction With an annual world production of around milli
2019-10-15
Introduction With an annual world production of around 750 million tons, wheat is grown on more agricultural area than any other food crop and is the main source of plant protein in human nutrition [1,2]. Wheat is composed of 8–15% protein, from which 85–90% is gluten [3]. The unique viscoelastic a
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br Experimental Procedures br Author Contributions
2019-10-14
Experimental Procedures Author Contributions Acknowledgments Introduction Estrogen-related receptors (ERRα, ERRβ, and ERRγ) are orphan nuclear receptors whose physiological ligands have not yet been identified. Although ERRs are closely related to estrogen receptors (ERs) they do not res
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Little information is available regarding the
2019-10-14
Little information is available regarding the expression of the different EP receptor subtypes on human monocytic cells, particularly those that are involved in downregulating cytokine production. The receptors are controlled by the respective genes for each receptor i.e. PTGER1–PTGER4 for EP1–EP4 r
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In the present study we first examined the in vivo
2019-10-14
In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 W146 in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and methods Re
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Studies using SERPINB deficient mice established the signifi
2019-10-14
Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi
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br Experiments and Methods br Results and Discussion br
2019-10-14
Experiments and Methods Results and Discussion Conclusions Here, the interactions between two newly-synthesized carbazole derivative—cationic δ,δ′‑diazacarbazoles and DNA were characterized by several spectroscopic means, including UV–Vis and fluorescence, AFM and fluorescence imaging. The
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